Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity

Objectives: To assess and compare the quantity quality of newly bone generated when using chitosan-based gel scaffold osteoprotegerin-chitosan scaffold. Methods: A total 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan or was implanted last six kept unfilled as a control. Bone formation examined at 6 weeks. Bone’s specimens scanned High-resolution peripheral quantitative computed tomography. Histological histomorphometric analysis carried out to volume area regenerated bone. Results: The results HR-pQCT showed that densities in group significantly higher than control groups whereas, density both intervals time ( p = 0.01, 000). No significant difference between 0.506, 0.640) observed. However, similar findings shown analysis, with highest new observed OPG-chitosan followed by group. mean percentage greater weeks compared all groups. Conclusions: Chitosan-based demonstrated surgical defects. Consistently, osteoprotegerin enhanced regeneration.